In the pre-clinical phase of translational research, we work with multidisciplinary groups to evaluate these possible interventions before they become clinical trials. Broadly, we are interested in finding new ways to address diseases such as autoimmunity, inflammatory cytokine storms, and cancers.
In the laboratory, we collaborate with other biologists, marine biologists, chemists, and professionals in the biotech and pharma industries to elucidate how novel natural and synthetic compounds change immune responses. We also bioprospect ocean algae for active compounds that may be used to treat a variety of medical conditions such as chronic inflammation and cancer.
We characterize how naturally occurring marine neurotoxins influence human cell responses through several mechanism of action studies. We develop bioassays to support pre-clinical discovery and development. This research should help identify potential targets for clinical trials.
In our non-laboratory research program, we work with a multidisciplinary team in the School of Nursing to measure caregiver burden associated with caring for patients with the aggressive and incurable brain cancer, Glioblastoma Multiforme (GBM). The goal of this work is to better understand the needs associated with GBM caregivers so better support and intervention can be developed.
The Translational Medicine Lab consists of both the McCall Lab and the Minns Lab, located at Center for Marine Science at the University of North Carolina Wilmington.
