Faculty & Staff

Stephen T. Kinsey, Professor & Graduate Coordinator

http://people.uncw.edu/kinseys/Ph.D., Biological Science, Florida State University, Tallahassee, FL, 1996
M.S., Marine Science, University of South Florida, St. Petersburg, FL, 1991
B.S., Biological Science, Old Dominion University, Norfolk, VA, 1987
Dobo Hall 219 | (910) 962-7398 | 601 South College Road, Wilmington, NC 28403-5915
kinseys@uncw.edu | http://people.uncw.edu/kinseys/

Our lab is broadly interested in comparative physiology and biochemistry, with an emphasis on how cellular processes affect complex, whole animal phenotypic traits. Much of our effort at the cellular level is directed at understanding muscle energetics and the metabolic principles that drive cellular design. That is, we try to understand how biochemistry works in living cells, accounting for such features as metabolic organization and intracellular diffusion. Our studies of muscle function are then used to define aspects of whole animal behavior, such as the limits to burst escape locomotion or exercise endurance. We study marine invertebrates (such as crabs and lobsters) and fishes because of the extreme diversity in structure and function found in tissues from these organisms, as well as mice, which are excellent biomedical models. We use several experimental techniques that allow us to non-invasively probe metabolism in living cells, including nuclear magnetic resonance (NMR), magnetic resonance imaging (MRI), and confocal microscopy, as well as invasive approaches such as cDNA microarray analysis, spectrophotometric assays, muscle contraction measurement, and electron/light microscopy.

Jimenez, A.G., R.M. Dillaman and S.T. Kinsey (2013). Large fibre size in skeletal muscle is metabolically advantageous. Nature Communications 4:2150. DOI 10.1038/ncomms3150.

Pathi, B., S.T. Kinsey and B.R. Locke (2013). Oxygen control of intracellular distribution of mitochondria in muscle fibers. Biotechnology and Bioengineering. 110(9): 2513-2524. DOI 10.1002/bit.24918.

Velten, B.P., R.M. Dillaman, S.T. Kinsey, W.A. McLellan and D.A. Pabst (2013). Novel locomotor muscle fiber design in extreme deep-diving whales. Journal of Experimental Biology. 216: 1862-1871.

Kielhorn, C.E., R.M. Dillaman, S.T. Kinsey, W.A. McLellan, D.M. Gay, J.L. Dearolf and D.A. Pabst (2013). Locomotor muscle profile of a deep (Kogia breviceps) versus shallow (Tursiops truncatus) diving cetacean. Journal of Morphology 274:663–675.

Priester, C., J.P. Braude, L.C. Morton, S.T. Kinsey, W.O. Watanabe and R.M. Dillaman. (2012). Ring bands in fish skeletal muscle: Reorienting the myofibrils and microtubule cytoskeleton in a single cell. Journal of Morphology 273(11):1246-56.

Pathi, B., S.T. Kinsey, C. Priester, M. E. Howdeshell, R.S. McNeill and B.R. Locke. (2012). The formation and functional consequences of heterogeneous mitochondrial distributions in skeletal muscle. Journal of Experimental Biology 215:1871-1883.

Jimenez, A.G and S.T. Kinsey. (2012). Nuclear DNA content variation associated with muscle hypertrophic growth in fishes. Journal of Comparative Physiology B 182: 531-540.

Dasika, S., S.T. Kinsey, and B.R. Locke. (2012). Facilitated diffusion of myoglobin and creatine kinase and reaction-diffusion constraints of aerobic metabolism under steady state conditions in skeletal muscle. Biotechnology and Bioengineering 109(2): 545–558.

Dasika, S., S.T. Kinsey, and B.R. Locke. (2012). Sensitivity analysis of reaction-diffusion constraints in muscle energetics. Biotechnology and Bioengineering 109(2): 559–571.

Jimenez, A.G., S.K. Dasika, B.R. Locke, and S.T. Kinsey. (2011). An evaluation of muscle maintenance costs during fiber hypertrophy in the lobster, Homarus americanus: Are larger muscle fibers cheaper to maintain? Journal of Experimental Biology. 214:3688-3697.

Pathi, B., S.T. Kinsey, and B.R. Locke. (2011). Influence of reaction and diffusion on spatial organization of mitochondria and effectiveness factors in skeletal muscle cell design. Biotechnology and Bioengineering. 108(8): 1912-1924.

Priester, C., L.C. Morton, S.T. Kinsey, W.O. Watanabe, and R.M. Dillaman. (2011). Diffusion influences on muscle fiber growth patterns and nuclear distribution in fish white muscle. Journal of Experimental Biology. 214:1230-1239.

Kinsey, S.T., B.R. Locke, and R.M. Dillaman. (2011). Molecules in motion: influences of diffusion on metabolic structure and function in skeletal muscle. Journal of Experimental Biology 214:263-274 (invited paper).

Dasika, S.K., S.T. Kinsey and B.R. Locke. (2011). Reaction-diffusion constraints in living tissue: effectiveness factors in skeletal muscle design. Biotechnology and Bioengineering. 108(1):104-1145.

Burpee, J.L., E.L. Bardsley, R.M. Dillaman, W.O. Watanabe and S.T. Kinsey. (2010). Scaling with body mass of mitochondrial respiration from the white muscle of three phylogenetically, morphologically and behaviorally disparate teleost fishes. Journal of Comparative Physiology B. 180:967–977.

Jimenez, A.G., S.T. Kinsey, R.M. Dillaman and D.F. Kapraun. (2010). Nuclear DNA content variation associated with muscle fiber hypertrophic growth in decapod crustaceans. Genome 53:161-171.

Hardy, K.M., S.C. Lema and S.T. Kinsey. (2010). The metabolic demands of swimming behavior influence the evolution of skeletal muscle fiber design in the brachyuran crab family Portunidae. Marine Biology 157(2):221-236. Online supplementary material: DOI: 10.1007/s00227-009-1301-3.

Hardy, K.M., R.M. Dillaman, B.R. Locke and S.T. Kinsey. (2009). A skeletal muscle model of extreme hypertrophic growth reveals the influence of diffusion on cellular design. American Journal of Physiology, Integrative Comparative and Regulatory Physiology. 296:R1855-R1867 (Summary article of work highlighted in Outside JEB, a review of literature in the Journal of Experimental Biology).

Overton, J.D., G.S. Adams, R.D. McCall and S.T. Kinsey. (2009). High energy phosphate concentrations and AMPK phosphorylation in skeletal muscle from mice with inherited differences in hypoxic exercise tolerance. Comparative Biochemistry and Physiology A 152: 478-485.

Locke, B.R. and S.T. Kinsey. (2008). Diffusional constraints on chemical reactions in skeletal muscle. Journal of Theoretical Biology 254:417-429.

Jimenez, A.G., B.R. Locke and S.T. Kinsey. (2008). The influence of oxygen and high-energy phosphate diffusion on metabolic scaling in three species of tail-flipping crustaceans. Journal of Experimental Biology 211:3214-3225.

Kinsey, S.T., K.M. Hardy and B.R. Locke. (2007). The long and winding road: influences of intracellular metabolite diffusion on cellular organization and metabolism in skeletal muscle. Journal of Experimental Biology. 210:3505-3512 (invited paper).

Nyack, A.C., B.R. Locke, A. Valencia, R.M. Dillaman and S.T. Kinsey. (2007). Scaling of post-contractile phosphocreatine recovery in fish white muscle: effect of intracellular diffusion. American Journal of Physiology, Integrative Comparative and Regulatory Physiology. 292: R2077-R2088.

Hardy, K.M., B.R. Locke, M. Da Silva and S.T. Kinsey. (2006). A reaction-diffusion analysis of energetics in large muscle fibers secondarily evolved for aerobic locomotor function. Journal of Experimental Biology 209: 3610-3620.

Kinsey, S.T., K.M. Hardy and B.R. Locke. (2007). The long and winding road: influences of intracellular metabolite diffusion on cellular organization and metabolism in skeletal muscle. Journal of Experimental Biology. 210:3505-3512.

Kinsey, S.T., P. Pathi, K.M. Hardy, A. Jordan and B.R. Locke.  (2005). Does intracellular metabolite diffusion limit post-contractile recovery in burst locomotor muscle?  Journal of Experimental Biology 208: 2641-2652.

Johnson, L.K., R.M. Dillaman, D.M. Gay, J.E. Blum and S.T.Kinsey.  (2004).  Metabolic influences of fiber size in aerobic and anaerobic muscles of the blue crab, Callinectes sapidus.  Journal of Experimental Biology  207: 4045-4056. 


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