Department of Psychology

David A. MacQueen

David A. MacQueen

Dr. David A. MacQueen, Assistant Professor
PhD in Clinical Psychology, University of South Florida, 2015
MA in Clinical Psychology, UNCW, 2009
BS in Business Administration, UNCW, 2006

Teaching Laboratory Building, Rm 3033 (Lab 3017)
601 South College Road, Wilmington, NC 28403
(910) 962-0539.

email | ResearchGate Profile | Google Scholar Profile

My research focuses on using translational methods to improve the efficiency of psychiatric drug development, and to explore the neurobiological underpinnings of cognition. Much of my work in this area has focused on the development of cognitive tasks which can be similarly tested in multiple species (i.e., cross-species tasks). These tasks are then used to evaluate the consistency of gene and drug effects (as well as other manipulations) across species. With modern technology it has become easier to generate new drug compounds. However, for every 5,000 new drugs which begin animal testing, only 1 is likely to complete human trials and be approved by the FDA for use. My lab seeks to develop testing paradigms which enhance the predictive validity of animal models for human behavior. The selection of behaviors/phenotypes modeled in my lab is guided by my work as a clinical psychologist.

At present, my lab is focused on developing a battery of tests for the Automated Rating of Olfactory Mental Acuity (AROMA). AROMA testing utilizes an olfactometer to program timed presentations of odors to human participants, and to record behavioral responses. Tasks designed with this equipment are modeled after olfactory testing procedures used in rodents. As a result of their olfactory acuity, rodents are often able to be more rapidly trained and complete more complex cognitive tasks with olfactory stimuli. The development of human AROMA procedures will allow for an evaluation of the relevance of rodent odor tasks to human behavior/cognition.

Select Publications

MacQueen, D. A., Minassian, A., Kenton, J. A., Geyer, M. A., Perry, W., Brigman, J. L., & Young, J. W. (2018). Amphetamine improves mouse and human attention in the 5-choice continuous performance test. Neuropharmacology. doi:10.1016/j.neuropharm.2018.05.034

MacQueen, D. A., & Drobes, D. J. (2017). Validation of the human odor span task: effects of nicotine. Psychopharmacology (Berl), 234(19), 2871-2882. doi:10.1007/s00213-017-4680-z

MacQueen, D. A., Heckman, B. W., Blank, M. D., Janse Van Rensburg, K., Park, J. Y., Drobes, D. J., & Evans, D. E. (2013). Variation in the alpha 5 nicotinic acetylcholine receptor subunit gene predicts cigarette smoking intensity as a function of nicotine content. Pharmacogenomics J. doi:10.1038/tpj.2012.50.