Department of Chemistry & Biochemistry

Biochemistry

Dr. Antje Almeida

Antje Almeida

  • Function and specificity of antimicrobial and cytotoxic peptides.
  • Movement of charged peptides across hydrophobic barriers.
  • Structure of bacterial membranes

Dr. Paulo Almeida

Paulo Almeida

  • Mechanism and kinetics of action of amphipathic defense peptides: how antimicrobial peptides and bacterial toxins attack their target cells.
  • Understanding biological membrane function: domain formation in fluid phospholipid membranes.
  • Cooperative magnification of small protein-lipid interactions and their functional consequences.

Dr. Chris Halkides

Chris Halkides

  • Chemical modification of signal transduction proteins
  • Crystallization of proteins
  • Synthesis of inhibitors against enzymes involved in amino acid biosynthesis
  • Testing of biodiesel

Dr. Conor Haney

Conor Haney

  • New methods for the site-specific incorporation of multiple post-translationally modified amino acids to understand how modifications affect protein aggregation
  • Peptide-based molecular probes for disease-related aggregates with improved specificity over current, small-molecule probes
  • Small molecule modulators of the cells’ inherent response to misfolded or aggregated proteins as a means to “rescue,” protein misfolding

Dr. Soon Goo Lee

Soon Goo Lee

  • Molecular and structural basis of enzymes, regulatory proteins, and key signaling molecules using biochemical research tools, especially protein X-ray crystallography
  • The 'Genomic identification - Structure-based functional study - Protein/Metabolic engineering' strategy to understand and engineer the production of natural products

Dr. Ying Wang

Ying Wang

  • Molecular basis and pharmaceutical intervention of hereditary cataract formation
  • Protein engineering of highly soluble myoglobin inspired by deep-diving whales
  • Thermodynamics-guided formulation development of pharmaceutical proteins and peptides