New methods for the site-specific incorporation of multiple post-translationally modified amino acids to understand how modifications affect protein aggregation
Peptide-based molecular probes for disease-related aggregates with improved specificity over current, small-molecule probes
Small molecule modulators of the cells’ inherent response to misfolded or aggregated proteins as a means to “rescue,” protein misfolding
Dr. Soon Goo Lee
Molecular and structural basis of enzymes, regulatory proteins, and key signaling molecules using biochemical research tools, especially protein X-ray crystallography
The 'Genomic identification - Structure-based functional study - Protein/Metabolic engineering' strategy to understand and engineer the production of natural products