Biology & Marine Biology

Faculty & Staff

Daniel G. Baden, William R. Kenan, Jr. Distinguished Professor of Marine Sciences

Dr. BadenPh.D., Biochemistry, University of Miami, Miami, FL, 1977
B.A., Chemistry, Hamline University, St. Paul, MN, 1973
New Myrtle Grove Buillding 2001C | (910) 962-2408 ext. 2302 | Center for Marine Science,
5600 Marvin K. Moss Lane, Wilmington, NC 28409-5928 |

Our research emphasis pertains to natural toxins which interact specifically with receptor Site 1 (saxitoxin and tetrodotoxin), Site 2 (batrachotoxin, veratridine, and aconitine), and Site 5 (brevetoxins and ciguatoxin) associated with voltage-sensitive sodium channels. Our current molecular pharmacology work requires derivatization of each of these classes of toxin for use in biochemical investigations of the binding phenomena. Computer modeling of proposed derivatives, including structure-function relationships between receptor and toxin ligand, aids in our efforts to describe the 3-dimensional characteristics of each toxin binding site. A second avenue of research pertains to the development of specific binding assays for marine seafood toxins, with the express end product being colorometric detection kits for public health use. Current work centers on preparing immunological reagents for assay development, with future aspects involving the specific membrane-bound toxin receptor in in vitro microtitre plate formats and biosensor technology.

Baden, D.G., K.S. Rein, R.E. Gawley, G. Jeglitsch, and D.J. Adams. 1994. Is the a-ring lactone of brevetoxin PbTx-3 required for sodium channel orphan receptor binding and activity. Natural Toxins 2: 212-221. [Winner of Quintessence award 1994]

Poli, M.A., K.S. Rein, and D.G. Baden. 1995. Radioimmunoassay for the PbTx-2-type brevetoxins: eptiope specificity of two anti-PbTx sera. J. Assoc. Official Analyt. Chem. Intl. 78: 538-542.

Trainer, V.L., D.G. Baden, and W.A. Catterall. 1995. Detection of marine toxins using reconstituted sodium channels. J. Assoc. Official Analyt. Chem. Intl. 78: 499-508.