Faculty & Staff

Sonja J. Pyott, Assistant Professor

photoPh.D., Neuroscience, Stanford University, 2006
B.S., Biochemistry and Molecular Biology, Penn State University, 1999
Dobo Hall 222 | (910) 962-2323 | 601 S. College Road, Wilmington, NC 28403-5915

Research in my laboratory uses a variety of techniques, including patch clamp electrophysiology, histology, and transgenic mouse technology, to study molecular and cellular physiology.  Recent work studies how sensory hair cells in the cochlea, the mammalian hearing organ, are regulated by neurotransmitter receptors and ion channels.  These sensory cells provide a unique system to relate the contributions of single molecules to the physiology of the cell and the behaving (hearing) organism.

Pyott SJ, Meredith AL, Fodor AA, Yamoah, EN, Aldrich RW. (2007) Normal cochlear function in mice lacking the BK channel a, b1, or b4 subunits.  J Biol Chem 282:3312–3324.

Pyott SJ, Glowatzki E, Trimmer JS, Aldrich RW. (2004) Extrasynaptic Localization of Inactivating Calcium-Activated Potassium Channels in Mouse Inner Hair Cells.  J Neurosci 24:9469-9474.

Pyott SJ, Rosenmund C. (2002) The effects of temperature on vesicular supply and release in autaptic cultures of rat and mouse hippocampal neurons. J Physiol 539:523–535.

Rhee JS*, Betz A*, Pyott SJ*, Reim K, Varoqueaux F, Augustin I, Hesse D, Sudhof TC, Takahashi M, Rosenmund C, Brose N. (2002) Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by munc13s and not by PKCs. Cell 108:121–133. [*Equal contributors]

Colliver TL, Pyott SJ, Achalabun MA, Ewing AG (2000) VMAT mediated changes in quantal size and vesicular volume. J Neurosci 20:5276–5282.

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